Conversion of 1 7 a - Ethyny 1 - 4 - Estrene - 1 7 fi - ol to 1 7 a - Ethynyl - 1 9 - Nortestosterone in Rabbit Liver
نویسندگان
چکیده
Demonstration of remarkable biological effect of 3-deoxy-steroid confused the view about the mechanism of action of steroid,2) 3) while it has long been believed that the oxygen function at C-3 of steroid molecule is closely related to the mechanism of steroid action.1) 17a-Ethyny1-4-estrene-178-ol (ethynyl-estrenol) is one such compound which has no oxygen function at C-3 and shows remerkable progestational activity.4) In the studies reported here, the conversion of ethynyl-estrenol to 17a-ethyny1-19nortestosterone (ethynyl-nortestosterone) have been demonstrated by the incubation with rabbit liver homogenates.
منابع مشابه
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17B-ol-3-one, 5( 10)-estren17/3-ol-3-one, an isomer each of 5-estrane-3,17-diol and estradiene-3,17-diol and two isomers each of S( 10)-estren-3-ol-17-one and S( l0)-estrene3,17-diol were identified. None of these steroids was detected in the blank incubated samples. In the blank phenolic fractions traces of oestrone and oestradiol-17P were present. In the post-incubation extracts a definite in...
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